Testosterone Cypionate Dosage: What Labels Say

Short answer: The testosterone cypionate dosage printed on the FDA-approved label for men with hypogonadism is a range, not a single number: 50 to 400 mg every two to four weeks, injected into muscle. The label says the dose depends on the patient and is adjusted to response and side effects. Your prescriber decides the dose. This page reports what the labels, the research and the clinics publish, and it does not recommend an amount.

Independently researched. Last reviewed October 26, 2026. Educational information only, not medical advice. Affiliate disclosure.

People search for a testosterone cypionate dosage because they want a number to compare with a prescription, a clinic offer or something they read on a forum. The honest answer is that the official number is wide on purpose. Below is what the Depo-Testosterone prescribing information on DailyMed says, how the newer Azmiro label words it, what the evidence on under-the-skin injections shows, and what online clinics publish about their own protocols and prices. For every clinic we review that offers injections, see the injectable TRT hub.

What testosterone cypionate dosage does the FDA label give?

The Depo-Testosterone label says that for replacement in the hypogonadal male, 50 to 400 mg should be given every two to four weeks. That is the whole official testosterone cypionate dosage statement for adult replacement. It is a band that runs eight-fold from bottom to top, with an interval that can double.

The same label explains why it is a band. It says the suggested dosage varies depending on the age, sex and diagnosis of the individual patient, and that it is adjusted according to the patient's response and the appearance of adverse reactions. In plain terms: the label hands the decision to the prescriber and tells them to adjust it.

A newer FDA-approved cypionate product, Azmiro, sold in a prefilled syringe, uses almost the same words. Its label gives a recommended dosage of 50 mg to 400 mg every two to four weeks as a deep intramuscular injection into the gluteal muscle, and says the dose and schedule are individualized. The Azmiro label, section 2.5, restricts the prefilled syringe to a 200 mg dose administered by a healthcare professional. Other doses in the general range require the single-dose vial; the syringe is not an adjustable 50–400 mg presentation.

One sentence in the Azmiro prescribing information matters for anyone comparing numbers across products: injectable testosterone products may have different doses, strengths or administration instructions, and they are not substitutable on a milligram-per-milligram basis. A number that fits one product cannot simply be carried over to another.

Why is the label range so wide?

Because the label describes the drug, not you. Two men with the same symptoms can absorb and clear testosterone differently, and the label's instruction to adjust dosing to response is how that difference is handled. The Endocrine Society's clinical practice guideline suggests that clinicians aim at achieving testosterone concentrations in the mid-normal range during treatment, which is a target for blood levels and not an amount of drug.

Before any of that, the diagnosis has to be right. The Depo-Testosterone label asks prescribers to confirm hypogonadism by checking that serum testosterone was measured in the morning on at least two separate days and was below the normal range. The Endocrine Society guideline likewise recommends confirming the diagnosis by repeating the measurement of morning fasting total testosterone.

The label also explains how long one injection works. It gives the half-life of testosterone cypionate injected into muscle as approximately eight days, according to the Depo-Testosterone prescribing information. That is the pharmacology behind an interval of weeks rather than days. It does not tell you which interval suits a given patient.

The vial strength is a separate number again. The label lists two strengths, 100 mg/mL and 200 mg/mL. The same volume drawn from different vials holds different amounts of drug, which is one more reason a testosterone cypionate dosage copied from someone else's syringe means little.

Is subcutaneous testosterone cypionate an option?

Not according to the cypionate labels. The Depo-Testosterone label says injections should be given deep in the gluteal muscle, and that the product is for intramuscular use only. Giving testosterone cypionate subcutaneously, under the skin rather than into muscle, is a prescriber's off-label choice.

There is one FDA-approved testosterone injection made for the skin layer, and it is a different ester. The Xyosted label describes testosterone enanthate injection for subcutaneous use in an autoinjector. That label says to avoid intramuscular and intravascular administration, and it puts the injection in the abdominal region once a week.

What does the research on under-the-skin injections show?

The studies are small and mostly not in the population this site covers. A 2017 study by Spratt and colleagues looked at female-to-male transgender patients, not men with hypogonadism. In that group, serum testosterone within the normal male range was achieved in all 63 patients on subcutaneous injections. All 22 patients who had switched from intramuscular injections preferred the subcutaneous route.

A second small study, by McFarland and colleagues, followed eleven transgender patients already on weekly subcutaneous testosterone cypionate. It reported that mean total and free testosterone stayed stable and within the normal range between injections. Its authors anticipated that the results could extend to hypogonadal men, which is a hypothesis rather than a finding.

The one comparison we found in hypogonadal men did not test subcutaneous cypionate. A 2022 study by Choi and colleagues compared 234 hypogonadal men on intramuscular cypionate with men on the subcutaneous enanthate autoinjector. The type of treatment was not associated with total testosterone after adjustment, and the autoinjector group had lower estradiol and lower hematocrit after treatment.

Read together, the evidence suggests under-the-skin injection can work and many patients like it. It does not establish an equivalent testosterone cypionate dosage for the subcutaneous route, and none of these studies is a dosing guide.

Where are testosterone cypionate injection sites?

On the label, there is one: deep in the gluteal muscle. The Depo-Testosterone label says intramuscular injections should be given deep in the gluteal muscle and the drug must not be given intravenously. The Azmiro label gives the same site.

Clinics that prescribe self-injection often teach other sites, and they do so under their own clinical protocols. We do not list sites or techniques here, because the person who prescribes the drug should show you how and where to inject it, and should check that you can do it safely. Ask for that training before the first dose, not after.

The label's list of adverse reactions includes inflammation and pain at the site of intramuscular injection. Report a site that stays painful, swollen or red to the prescriber.

What do online clinics publish about their dosing?

Some clinics put protocol details on their sales pages. These are their statements about their own service, read on their own pages, and not dosing advice from us.

Male Excel describes a daily protocol. Its HRT costs page, read October 26, 2026, lists "Once daily injectable Bioidentical Testosterone Cypionate" shipped with "60 insulin-type subcutaneous syringes/needles". That is a subcutaneous protocol, which the cypionate labels do not cover. See the Male Excel review.

Peter MD states a ceiling. Its two-month TRT plan page, read October 26, 2026, lists "Testosterone Cypionate: up to 200mg weekly". See the Peter MD review.

Gameday Men's Health describes a frequency. Its telehealth page, read October 26, 2026 (ldr.gamedaymenshealth.com), says injections are "Weekly or bi-weekly, in-clinic or self-administered at home". See the Gameday review.

LifeMD lists testosterone cypionate as an intramuscular treatment on its men's health page, read October 26, 2026. See the LifeMD review.

Weekly or daily protocols split the label's total into smaller, more frequent shots. That is a common clinical practice, but the label itself speaks in intervals of two to four weeks. If a clinic's protocol differs from the label, it is fair to ask the prescriber why, and how they will check that it is working.

How much are testosterone shots at online clinics?

Partner clinics come first below, each box with the injection prices we have checked, their plan length and the date each was checked; the other clinics that publish an injection price are named under them, and their reviews give the figure. Prices are what the clinic charges for its plan, not for a particular testosterone cypionate dosage.

Some clinics price their injection plan as a membership tier rather than a product, and we list those too:

Read the plan terms before comparing. A figure "plus the membership" is not an all-in monthly cost, a prepaid term is billed upfront, and a 4-week price is not the same as a calendar-month price. The cheapest TRT comparison puts every clinic's starting price side by side, and our TRT cost per month guide explains how to compare plans with different terms.

Which risks does the label ask prescribers to watch?

Dose and monitoring go together, which is why the label talks about both. The Depo-Testosterone label says hemoglobin and hematocrit should be checked periodically in patients on long-term treatment. The same label warns that testosterone can increase blood pressure, which can raise cardiovascular risk over time.

Testosterone is also a controlled drug. The Depo-Testosterone label states that it contains testosterone, a Schedule III controlled substance. A legitimate supply comes with a prescription from a licensed clinician after an assessment, never from a seller who skips that step. Our guide to avoiding TRT scams explains the warning signs.

For the wider list of effects and what the evidence says about them, see TRT side effects. If fertility matters to you, testosterone can suppress sperm production, and our fertility guide covers what the evidence shows.

How do injections compare with other forms?

Injections are one of several ways to take testosterone. A gel is applied daily to the skin, an oral capsule is swallowed, and pellets are implanted under the skin for months. Each has its own label and its own dose. Our comparison of injectable, cream and oral TRT and the guide to oral testosterone versus injections cover the trade-offs, and the testosterone gel 1.62% guide reports that label's dosing.

Frequently asked questions about testosterone cypionate dosage

What is the normal testosterone cypionate dosage for TRT?

There is no single normal dose. The FDA label for hypogonadal men gives a range of 50 to 400 mg every two to four weeks and says the prescriber adjusts it. The dose for you is the one your prescriber sets after testing, and it can change with follow-up results.

Is a weekly testosterone cypionate dosage different from the label?

The label speaks in intervals of two to four weeks. Many clinics split treatment into weekly or even daily injections under their own protocols. Ask your prescriber how their schedule relates to the label and how they will monitor it.

Can testosterone cypionate be injected subcutaneously?

The cypionate labels say intramuscular use only, so subcutaneous use is off-label. Small studies, mostly in transgender patients, found subcutaneous injections kept levels in range and that patients preferred them. Only your prescriber can decide whether that route suits you.

How much are testosterone shots per month online?

It depends on the clinic and the plan length. The lists above give the injection prices we have checked, with each plan's terms and check date. Several are prepaid terms or charges on top of a membership, so compare the total you would pay.

Should I change my dose if I feel no difference?

No. Talk to the prescriber. The label ties adjustments to the patient's response and to side effects, which means blood tests and a clinical review, not a change made at home.

Related reading and clinic reviews

• Injectable TRT: every clinic we review that offers it
• Male Excel review, Peter MD review and DudeMeds review
• Hone Health review and GobyMeds review
• Injectable vs cream vs oral TRT
• TRT side effects

Medical disclaimer: Educational information only, not medical advice. The dose of any testosterone product is decided by the licensed clinician who prescribes it. This page reports what labels, studies and clinics publish and is not a dosing or self-injection guide. Some links lead to partner clinics; see our affiliate disclosure. Labels and clinic pages read October 26, 2026.